Publication Abstract

17alpha, 20beta-dihydroxy-4-pregnen-3-one 20-sulphate: a major new metabolite of the teleost oocyte maturation-inducing steroid

17alpha, 20beta-dihydroxy-4-pregnen-3-one 20-sulphate: a major new metabolite of the teleost oocyte maturation-inducing steroid

A.P.Scott and A.V.M. Canario

This paper describes the discovery of 17 alpha, 20 beta -dihydroxy-4-pregnen-3-one 20-sulphate (17, 20 beta -P-sulphate) in urine of male and female plaice Pleuronectes platessa , in female Atlantic salmon Salmo salar and in female Dover sole Solea solea. 17 alpha, 20 beta -dihydroxy-4-pregnen-3-one (17, 20 beta -P) induces oocyte final maturation in teleosts and, whereas levels of the free steroid in maturing/ovulating female plaice are generally < 1 ng/ml and poorly associated with the stage of maturation, the levels of 17, 20 beta -P-sulphate are around 1500 ng/ml urine, 11 ng/ml blood plasma and six-fold higher in maturing than in nonmaturing fish. There are also high levels in spermiating male plaice (ca. 2300 ng/ml urine and 20 ng/ml blood plasma).

Reference:

A.P.Scott and A.V.M. Canario, 1992. 17alpha, 20beta-dihydroxy-4-pregnen-3-one 20-sulphate: a major new metabolite of the teleost oocyte maturation-inducing steroid. General and Comparative Endocrinology, 85: 91-100.

A.P.Scott* and A.V.M. Canario

General and Comparative Endocrinology, 85: 91-100