Publication Abstract

Malachite green: a pharmacokinetic study in rainbow trout, Oncorhynchus mykiss (Walbaum)

D.J. Alderman and R.S. Clifton-Hadley

Pharmacokinetic studies on uptake, distribution and climination of malachite green in rainbow trout, Oncorhynchus mykiss (Walbaum), are described. All three processes were found to be temperature-dependent, with levels and rates increasing with increases in water temperature. Tissues investigated were serum, liver, kidney, muscle and viscera. First-order kinetics were found to apply and, in particular, kidney was observed to be a deep compartment. The long-term persistence of kidney residues may explain the efficacy of malachite green for the control of proliferative kidney disease in rainbow trout. Residue levels in muscle were never excessive and an extrapolation from the experimental data suggests that a suitable withholding period might be 600 degree days.

Reference:

D.J. Alderman and R.S. Clifton-Hadley, 1993. Malachite green: a pharmacokinetic study in rainbow trout, Oncorhynchus mykiss (Walbaum). Journal of Fish Diseases, 16(4): 297-311