Publication Abstract
- Title
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Pro-Oxidant, Antioxidant and 7-Ethoxyresorufin O-Deethylase (Erod) Activity Responses in Liver of Dab (Limanda limanda) exposed to Sediment Contaminated with Hydrocarbons and other Chemicals
- Publication Abstract
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Pro-Oxidant, Antioxidant and 7-Ethoxyresorufin O-Deethylase (EROD) Activity Responses in Liver of Dab (Limanda limanda) exposed to Sediment Contaminated with Hydrocarbons and other Chemicals
D.R. Livingstone, P. Lemaire, A. Matthews, L.Peters, D. Bucke and R.J. Law
Dab were exposed to reference sediment (79 µg PAHs g-1 dry wt) or contaminated sediment (309 µg PAHs g-1 dry wt plus low PCBs) for up to 140 days, and the effects on liver cytochrome P4501A (EROD activity), antioxidant enzymes and oxidative damage (lipid peroxidation) examined. EROD activity in the contaminated condition increased X 80 from 25 to 80 days, decreasing to 22% of this activity after 140 days. EROD activity also increased in the reference condition, but only after 140 days. Superoxide dismutase (SOD) and catalase activities and lipid peroxidation (malonaldehyde equivalents) were higher in the contaminated than the reference condition after 80 days but not 140 days. No differences were seen in glutathione peroxidase activity. It is concluded that the changes in SOD, catalase and lipid peroxidation are indicative of contaminant-mediated oxidative stress.
Reference:
D.R. Livingstone, P. Lemaire, A. Matthews, L.Peters, D. Bucke and R.J. Law, 1993. Pro-Oxidant, Antioxidant and 7-Ethoxyresorufin O-Deethylase (EROD) Activity Responses in Liver of Dab (Limanda limanda) exposed to Sediment Contaminated with Hydrocarbons and other Chemicals. Marine Pollution Bulletin, 26(11): 602-606
- Publication Internet Address of the Data
- Publication Authors
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D.R. Livingstone, P. Lemaire, A. Matthews, L.Peters, D. Bucke and R.J. Law*
- Publication Date
- January 1993
- Publication Reference
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Marine Pollution Bulletin, 26(11): 602-606
- Publication DOI: https://doi.org/
