Publication Abstract

Biological response of fish cell cultures and sticklebacks to cadmium and silver nanoparticles

Matthew Sanders. Feb 27, 2009, Nanotoxicology: Health & Environmental Impacts, Welwyn Garden City, U.K

Nanotechnology is a rapidly developing field, attracting investment from industry and governments. The range and variety of nanomaterials available is likely to require a specific risk assessment for each new compound with associated fit for purpose testing procedures. We are developing a tiered testing approach using cadmium (4nm ±1nm) and silver (13nm ± 7nm) nanoparticles, which comprises an initial screen for cellular toxicity using cultured cells, followed by standardised (OECD) whole organism ecotoxicology tests using the freshwater Crustacean Daphnia magna. Finally the estuarine fish stickleback (Gasterosteus aculeatus) will be used to assess a range of toxicological, behavioural and reproductive endpoint.